Metabolite Profiling of Ficus deltoidea’s Most Active Fraction as Anti-Candida albicans Using UPLC-QToF-MS/MS

Background: Ficus deltoidea is a medicinal plant known for treatment by ethnic Dayaks, Kalimantan and called Tabat Barito. Empirically, the majority of Barito leaves are used to treat candidiasis. Scientific data on F. activity in its against candidiasis or candida still minimal. Metabolite profiling from most active fraction Candida has not been reported. Objectives: This study aimed explore part deltoidea leaves C. albicans obtaining identification compounds through metabolite using UPLC-QToF-MS/ MS. Methods: The were macerated solvents with an increase polarity, fractionation was done column chromatography, while antifungal assay carried out diffusion method. LC-MS/MS. Results: Assay results extracts showed that best owned ethyl acetate extracts, inhibition zone more than 10 mm. The strongest shown FrEA5 30.67 ± 1.155 mm, stronger Voriconazole as positive control zone: 19.75 0.5 metabolites can be identified Nigeglanine; 1,1,2,3,3-Pentamethylindane; 1,1’-(1,1-Ethenediyl)bis(3-methylpiperazine). Conclusion: research shows contained include 1,1’-(1,1-Ethenedyl)bis(3- methylpiperazine). justify;">Key words: albicans, Ficus deltoidea, FrEA5, Profiling, UPLC-QToF-MS/MS.